[Download] "Coarse-Grained Modelling of DNA and DNA Self-Assembly" by Thomas E. Ouldridge " eBook PDF Kindle ePub Free

eBook details

Title: Coarse-Grained Modelling of DNA and DNA Self-Assembly
Author : Thomas E. Ouldridge
Release Date : January 09, 2012
Genre: Life Sciences,Books,Science & Nature,Professional & Technical,Engineering,Physics,
Pages : * pages
Size : 3635 KB

Description

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.